Argentina forward Angel di Maria ran onto a perfectly timed pass from Karim Benzema to open the scoring in the 72nd minute. Jose Callejon then followed up with a goal in the 89th minute and another in injury time.
The Santiago Bernabeu meanwhile welcomed Denis Cheryshev , who became the first Russian to start a match for Madrid .
In other round of 32 matches, Real Betis, Las Palmas, Cordoba, Osasuna and Malaga also went through.
During the match, sections of the Bernabeu crowd chanted Jose Mourinho's name , although it was unclear if they were doing so in support of the embattled manager or in a mocking fashion.